Muscarinic acetylcholine receptors coupled to a Gαi protein & found in cardiac muscles. 

TLS Online TPP Program

#Id: 4744

#Unit 5. Developmental Biology

TLS Online TPP Program

#Id: 4745

#Unit 5. Developmental Biology

PKC-3 restricts PAR-1 and PAR-2 to the internal cytoplasm by phosphorylating them.

TLS Online TPP Program

#Id: 4746

#Unit 5. Developmental Biology

Sperm microtubules contacts the cortical cytoplasm and initiates cytoplasmic movements that push the male pronucleus to the nearest end of the oblong oocyte.

TLS Online TPP Program

#Id: 4747

#Unit 5. Developmental Biology

Sperm microtubules protect PAR-2 protein from phosphorylation, allowing it to enter the cortex along with its binding partner, PAR-1.

TLS Online TPP Program

#Id: 4748

#Unit 5. Developmental Biology

Once PAR-1 is in the cortical cytoplasm, it phosphorylates PAR-3 causing PAR-3 and its binding partners PAR-6 and PKC-3 to leave the cortex.

TLS Online TPP Program

#Id: 4749

#Unit 5. Developmental Biology

At the same time, the sperm microtubules induce the contraction of the actin-myosin cytoskeleton toward the anterior, thereby clearing PAR-3, PAR-6, and PKC-3 from the posterior of the 1-cell embryo.