Asymmetric kinase dimer 

Receptor dimerization brings the kinase domains of the two subunits close together, so that the C lobe of one kinase domain binds to the N lobe of the other kinase domain

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In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

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In L cells, preproglucagon is processed primarily to glicentin, & glucagon-like polypeptides 1 and 2. Some oxyntomodulin is also formed

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In both A and L cells, residual glicentin-related polypeptide (GRPP) is left

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GLP-1 is processed further by removal of its amino-terminal amino acid residues and the product, GLP-1 (7–36), is a potent stimulator of insulin secretion

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#Unit 7. System Physiology – Animal

Glucagon is glycogenolytic, gluconeogenic, lipolytic, and ketogenic

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The glucagon receptor, found primarily on liver cells, is coupled to the Gαs protein, to activate adenylyl cyclase and increase intracellular cAMP