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TLS Online TPP Program

#Id: 9651


Phosphorylation by MEK at Y-185 and T-183 in activation loop of MAP kinase leads to a marked conformational change & promotes MAP kinase activation and dimerization.

#Unit 4. Cell Communication and Cell Signaling #RTK #Part B Pointers
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TLS Online TPP Program

#Id: 1358

#Unit 4. Cell Communication and Cell Signaling

GH, prolactin, G-CSF, thrombopoietin, and Epo evolved from a common ancestral protein.

TLS Online TPP Program

#Id: 1359

#Unit 4. Cell Communication and Cell Signaling

All cytokines have a similar tertiary structure consisting of four long conserved α helices folded together.

TLS Online TPP Program

#Id: 1360

#Unit 4. Cell Communication and Cell Signaling

Receptor Homodimerization GH, prolactin, G-CSF, thrombopoietin, and Epo have similar structures & they activate receptors of similar structure by forming dimers of two identical cytokine receptor proteins.
 

TLS Online TPP Program

#Id: 1361

#Unit 4. Cell Communication and Cell Signaling

Cytokine receptors activate tyrosine kinases in which receptor and kinase are separate polypeptides.

TLS Online TPP Program

#Id: 1362

#Unit 4. Cell Communication and Cell Signaling

In cytokine receptors, the tightly bound kinase is known as a JAK kinase.

TLS Online TPP Program

#Id: 1363

#Unit 4. Cell Communication and Cell Signaling

JAK kinases become activated after ligand binding and receptor dimerization.

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