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TLS Online TPP Program

#Question id: 1045

Why would it be more difficult to treat diseases in humans caused by members of the Eukarya than diseases caused by the Bacteria?

#Unit 4. Cell Communication and Cell Signaling

  1. Multicellular organisms always have their own immune systems to contend with-so any treatment we develop needs to overcome this built-in protection mechanism in such organisms.

  2. Since bacteria are so much simpler (being single-celled), they are inherently easier to kill off than multi-cellular eukaryotic microbes.

  3. Eukaryotic microbes use many of the same enzymes and systems as humans-so we lose the ability to target certain molecules that might be present ONLY in the cell type we want to eliminate. There's too much overlap when both organisms are eukaryotic.

  4. Eukaryotic microbes (unlike prokaryotes) often secrete compounds that breakdown and eliminate drugs used against them. This makes them much harder to effectively eliminate than bacteria.

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TLS Online TPP Program

#Question id: 32356

#Unit 1. Molecules and their Interaction Relevant to Biology

For given plot of hexokinase

 

a. i is representing Hexokinases IV

b. ii is representing Hexokinases I, II, and III

c. i is representing Hexokinases I, II, and III

d. ii is representing Hexokinases IV

Choose the correct option
TLS Online TPP Program

#Question id: 32357

#Unit 1. Molecules and their Interaction Relevant to Biology

There are two classes of aldolases such as;
A) Class I aldolases B) Class II aldolases
i) Found in animals and plants
ii) Found in fungi and bacteria
iii) formation of protonated Schiff base on enzyme and its active site contain lysine residue
iv) do not form the Schiff base intermediate and a zinc ion at the active site is coordinated with the carbonyl oxygen at C-2

In which of the following option is the given enzyme with its correct statements?
TLS Online TPP Program

#Question id: 32358

#Unit 1. Molecules and their Interaction Relevant to Biology

The first reaction in glycolysis that results in the formation of an energy-rich compound (i.e., a compound whose hydrolysis has a highly negative DG'°) is catalyzed by
TLS Online TPP Program

#Question id: 32359

#Unit 1. Molecules and their Interaction Relevant to Biology

 Column I (Terms) Column II (Match)
 A. Hexokinase 1. Competitive inhibitor
 B. Succinate dehydrogenase 2. Glycolysis enzyme
 C. Malonate 3. TCA cycle enzyme
 D. ATP synthase 4. Oxidative phosphorylation 
TLS Online TPP Program

#Question id: 32360

#Unit 1. Molecules and their Interaction Relevant to Biology

2-Deoxyglucose (2-DG) inhibits the proliferation of cells and hence finds use as an anti-cancer agent, inhibiting the activities of which of the following enzymes?
TLS Online TPP Program

#Question id: 32361

#Unit 1. Molecules and their Interaction Relevant to Biology

Phosphoglycerate mutase catalyses a reversible shift of the phosphoryl group between C-2 and C-3 of glycerate; which of the following ion is essential for this reaction