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TLS Online TPP Program

#Question id: 11840

During an ethylene signalling pathway, what will have done  inside cytosol and nucleus . Given below some prediction about presence and absence of ethylene in column B match with column A

            COLUMN A

                                           COLUMN B

I-  In the presence of ethylene

a)  ETR1 signaling is repressed and CTR1 is inactive

II- In the absence of ethylene

b)  ETR1 activate CTR1, a Ser/Thr kinase

 

c)  CTR1 phosphorylates the C-terminal domain of EIN2

 

d)  The nonphosphorylated C terminus of EIN2 is cleaved by a protease

 

e)  Phosphorylation of EIN2 inhibits proteolytic cleavage

 

f)  EIN3 transcription factors are ubiquitinated and degraded in the nucleus by the 26S proteasome

 

g)  EIN3 initiates a transcriptional cascade by activating expression of ethylene-responsive genes, including ERF1 transcription factor, leading to ethylene responses

 


#Unit 1. Molecules and their Interaction Relevant to Biology
  1. I-a, c and f; II-b, d, e and g
  2. I-a, d and g; II-b, c, e and f
  3. I-b, c, e and f;  II-a, d and g
  4. I-b, d, e and g; II-a, c and f
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TLS Online TPP Program

#Question id: 15298

#Unit 5. Developmental Biology

In mammalian development Prior to blastocyst formation, each embryonic blastomere expresses ________ transcription factors and appears to be capable of becoming either ICM or trophoblast.
TLS Online TPP Program

#Question id: 15299

#Unit 5. Developmental Biology

Name of transcription factor which are responsible for  pluripotency of  stem cells or stimulate the production of OCT4 and NANOG ;
TLS Online TPP Program

#Question id: 15300

#Unit 5. Developmental Biology

In hippo signaling pathway, the activation of the Cdx2 gene in the trophoblast cells appears to be regulated by the Yap protein, which in turn is a cofactor for the transcription factor Tead4. Tead4 is found in the ________blastocyst
TLS Online TPP Program

#Question id: 15301

#Unit 5. Developmental Biology

Initially, the morula does not have an internal cavity. However, during a process, cavitation, the trophoblast cells secrete fluid into the morula to create a blastocoel, these 
membranes of trophoblast cells contain_______?
TLS Online TPP Program

#Question id: 15302

#Unit 5. Developmental Biology

FOXP1 is a transcription factor which stimulate the production of Oct4 and Nanog and establish pluripotency. Which of the following statements are correct regarding to the mechanism of alternative splicing of FOXP1. 
A. There are two isoforms of the FoxP1 protein, One is the product of an mRNA spliced to include a particular exon, 18b, while the other splicing variant carries exon 18a.
B. When alternative splicing generates a form including exon 18b in place of 18a, the resulting isoform (FOXP1-ES) binds to a different DNA sequence and thus controls expression of a different set of genes.
C. The protein encoded by the exon 18b– carrying mRNA is called FOXP1-ES it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation. 
D. The exon 18a– containing form encodes FOXP1 itself, and this has the opposite effect: this activates genes that promote dedifferentiation, and thus stimulates iPS cell formation.
TLS Online TPP Program

#Question id: 15303

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by
a.  Loss of both alleles of NF1
b.  Mutation in RAS GAP-type protein
c.  A single mutant NF1 allele
d.  Mutation in SRC protein