The question refers to the following table, which compares the percent sequence homology of four different parts (two introns and two exons) of a gene that is found in five different eukaryotic species. Each part is numbered to indicate its distance from the promoter (for example, Intron I is the one closest to the promoter). The data reported for species A were obtained by comparing DNA from one member of species A to another member of species A.

Which of these four gene parts should allow the construction of the most accurate phylogenetic tree, assuming that this is the only part of the gene that has acted as a reliable molecular clock?

#Question id: 4411

#Unit 3. Fundamental Processes

All of the following are associated with vertebrate promoters located in active chromatin EXCEPT

#Question id: 4412

#Unit 3. Fundamental Processes

TATA less promoters without Inr and DCE are expressed

#Question id: 4413

#Unit 3. Fundamental Processes

Which of the following is true about TFIID?

#Question id: 4414

#Unit 3. Fundamental Processes

The helicase of TFIIH hydrolyzes the β-γ bond of ATP to catalyze open complex formation at Pol II promoters. ATP hydrolysis is also required by a step subsequent to transcription initiation, most likely promoter clearance. Transcriptional activation by TFIIH was assayed on linear and circular templates either in the presence of ATP and GTP or the nonhydrolyzable nucleotide analogs AMP-PNP and GMP-PNP with RNA Polymerase I. The following results were obtained. Choose plausible explanation for these results. 

A. ATP is required under conditions where TFIIH is indispensable for initiation. These conditions include transcription from promoters containing a short stretch of mismatched base pairs surrounding the transcriptional start site as well as on negatively supercoiled templates.

B. As Pol I transcription on linear templates requires neither ATP hydrolysis nor protein phosphorylation

C. in contrast to Pol II, the topology of the template does not affect the requirement for TFIIH and neither the ATPase, helicase, nor protein kinase activity of TFIIH are required for Pol I transcription activation.

#Question id: 4415

#Unit 3. Fundamental Processes

PML nuclear bodies are also sites of post-translational modification of proteins through the addition of

#Question id: 4416

#Unit 3. Fundamental Processes

The minor spliceosome recognizes rarely occurring introns having consensus sequences distinct from the sequences of most pre-mRNA introns. It should be emphasized that although these introns are rare, they are distributed in genome with frequency of