Rather than degradation, poly-K63 ubiquitin chains act as scaffolds that bind proteins that have a poly-K63 ubiquitin-binding domain

TLS Online TPP Program

#Id: 8904

#XL - T Zoology

TLS Online TPP Program

#Id: 8905

#XL - T Zoology

Most of the cohesins along the chromosome arms are removed from chromosomes during prophase, mediated by phosphorylation of cohesins by Plk1 & Aurora B kinase.

TLS Online TPP Program

#Id: 8906

#XL - T Zoology

TLS Online TPP Program

#Id: 8907

#XL - T Zoology

Centromere associated cohesins are specifically protected from phosphorylation dependent removal by protein phosphatase 2A

TLS Online TPP Program

#Id: 8908

#XL - T Zoology

Phosphatase is recruited to centromeric by the Shugoshin family of proteins

TLS Online TPP Program

#Id: 8909

#XL - T Zoology

Separase cleaves centromeric cohesin, triggering the onset of anaphase, releasing the sister chromatids