Rather than degradation, poly-K63 ubiquitin chains act as scaffolds that bind proteins that have a poly-K63 ubiquitin-binding domain

TLS Online TPP Program

#Id: 8914

#XL - T Zoology

Following securin degradation and a decrease in mitotic CDK activity, separase cleaves the Scc1 subunit, breaking the cohesin circles.

TLS Online TPP Program

#Id: 8915

#XL - T Zoology

Mitotic exit network plays an important role in shutting off mitotic cyclins by controlling the activation of the Cdc14 phosphatase through a GTPase pathway.

TLS Online TPP Program

#Id: 8916

#XL - T Zoology

Cytokinesis

With the exception of higher plants, the division of the cell is brought about by a contractile ring made of actin and myosin

TLS Online TPP Program

#Id: 8917

#XL - T Zoology

TLS Online TPP Program

#Id: 8918

#XL - T Zoology

Centralspindlin is a heterotetramer composed of two copies of the kinesin-6 motor protein MKLP1 and a dimer of a Rho GAP

TLS Online TPP Program

#Id: 8919

#XL - T Zoology

MKLP1 is inhibited by 14-3-3 to ensures that the spindle midzone microtubules do not compact until the end of anaphase