MCSs also serve as interfaces for the transfer of ions (Ca+2 ) and small molecules (glycerophospholipids) between the ER and mitochondria.

TLS Online TPP Program

#Id: 7911

#XL - Q Biochemistry

MCSs also serve as interfaces for the transfer of ions (Ca+2 ) and small molecules (glycerophospholipids) between the ER and mitochondria.

TLS Online TPP Program

#Id: 8156

#XL - Q Biochemistry

Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

TLS Online TPP Program

#Id: 8154

#XL - Q Biochemistry

Sar1 GTPase drives the pinching off of COPII vesicles

ARF GTPase drives the pinching off of COPIvesicles

Dynamin GTPase drives the pinching off of clathrin-coated vesicles

TLS Online TPP Program

#Id: 8153

#XL - Q Biochemistry

A second function of small GTPases in vesicle formation is in the pinching off of a completed vesicle from the parent membrane

TLS Online TPP Program

#Id: 8152

#XL - Q Biochemistry

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.

TLS Online TPP Program

#Id: 8151

#XL - Q Biochemistry

Sec12

acts as a GEF factor for Sar1

TLS Online TPP Program

#Id: 8150

#XL - Q Biochemistry

Sar1 is the only GTPase switch protein activated at the ER membrane