Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8625

#XL - T Zoology

Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 9687

#XL - T Zoology

In resting cells, the majority of the GLUT4 protein is

localized to specialized GLUT4 storage vesicles (GSVs)

TLS Online TPP Program

#Id: 9688

#XL - T Zoology

GSVs tethered to the Golgi matrix, by a protein termed TUG (Tether containing a UBX domain for GLUT4).

TLS Online TPP Program

#Id: 9689

#XL - T Zoology

Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

#Id: 9690

#XL - T Zoology

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.

TLS Online TPP Program

#Id: 9691

#XL - T Zoology

Movement of the GSVs to the plasma membrane is regulated by two monomeric GTP-binding proteins -RalA and Rab10

TLS Online TPP Program

#Id: 9692

#XL - T Zoology

Insulin receptor activates the PI-3 kinase/PKB pathway