In cytokine receptors, the tightly bound kinase is known as a JAK kinase.

#Id: 7911

#XL - Q Biochemistry

#Id: 7910

#XL - Q Biochemistry

Mitochondria-associated membranes (MAMs)

The portions of the ER membranes that form special contact regions with the mitochondria.

#Id: 7909

#XL - Q Biochemistry

#Id: 7908

#XL - Q Biochemistry

In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

#Id: 7907

#XL - Q Biochemistry

Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:

PINK1 (a kinase)

Parkin (E3 ubiquitin ligase)

#Id: 7906

#XL - Q Biochemistry