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TLS Online TPP Program

#Id: 9714

Ste11 analogous to Raf and other mammalian MEK kinase (MEKK) proteins.

#XL - T Zoology #Yeast Mating Pathways #Part B Pointers
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TLS Online TPP Program

#Id: 8346

#XL - Q Biochemistry

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase
TLS Online TPP Program

#Id: 8345

#XL - Q Biochemistry
TLS Online TPP Program

#Id: 8343

#XL - Q Biochemistry

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly
TLS Online TPP Program

#Id: 8342

#XL - Q Biochemistry
TLS Online TPP Program

#Id: 8341

#XL - Q Biochemistry

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks
TLS Online TPP Program

#Id: 8340

#XL - Q Biochemistry

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.