Eat me” signals

Dying cells facilitate their own phagocytosis by expressing on their surfaces such as phosphatidyl serine and lysophosphatidyl choline, proteins (annexin I), and altered carbohydrates. 

TLS Online TPP Program

#Id: 9672

#XL - T Zoology

In unstimulated cells, 

concentration of phosphoinositides is low, and PKB is

inactive because its PH domain physically blocks the kinase active site

TLS Online TPP Program

#Id: 9673

#XL - T Zoology

Ligand-induced receptor activation,

Concentration of PI 3-phosphates rises

PH domain of PKB binds to PI 3-phosphates

TLS Online TPP Program

#Id: 9674

#XL - T Zoology

Maximal activation of PKB depends on recruitment to the cytosolic surface of the plasma membrane of two other kinases -PDK1 and PDK2.

TLS Online TPP Program

#Id: 9675

#XL - T Zoology

PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop

TLS Online TPP Program

#Id: 9676

#XL - T Zoology

Phosphorylation by the mTORC2 kinase complex, of a second serine on

PKB that is not in the activation loop is necessary for maximal PKB activity

TLS Online TPP Program

#Id: 9677

#XL - T Zoology

Activated PKB directly phosphorylates and inactivates a protein Bad