ZnA and ZnB on RAG1 are regions of the proteins that form zinc fingers, elongated protein domains stabilized by the coordination of a Zn ion.

TLS Online TPP Program

#Id: 8705

#Unit 1. Molecules and their Interaction Relevant to Biology

The cytosolic isozyme has two distinct functions. It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis.

TLS Online TPP Program

#Id: 8706

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 8707

#Unit 1. Molecules and their Interaction Relevant to Biology

KDC shows Divergent evolution, in which the genes for an enzyme with one substrate specificity give rise, during evolution, to closely related enzymes with different substrate specificities but the same enzymatic mechanism.

TLS Online TPP Program

#Id: 8708

#Unit 1. Molecules and their Interaction Relevant to Biology

This reaction is catalyzed by nucleoside diphosphate kinase

TLS Online TPP Program

#Id: 8709

#Unit 1. Molecules and their Interaction Relevant to Biology

Malonate is an analog of succinate not normally present in cells, is a strong competitive inhibitor of succinate dehydrogenase, and its addition to mitochondria blocks the activity of the citric acid cycle.

TLS Online TPP Program

#Id: 4844

#Unit 1. Molecules and their Interaction Relevant to Biology