#Question id: 4515
#Unit 3. Fundamental Processes
Transcription Activators are,
A. Known to facilitate transcription at hundreds of promoters,
B. Specific for a few promoters,
C. Sensitive to the binding of signal molecules,
D. Providing the capacity to activate or deactivate transcription in response to a changing cellular environment.
#Question id: 4516
#Unit 3. Fundamental Processes
High mobility group (HMG) proteins
A. are a common type of architectural regulator
B. facilitating the looping of the DNA
C. the binding is relatively very specific
D. are abundant in chromatin and bind to DNA with limited specificity.
#Question id: 4517
#Unit 3. Fundamental Processes
Statement: When phosphorylated, CREB binds to CREs near certain genes and acts as a transcription factor, turning on the expression of these genes.
Explanation: I-Regulation can result from phosphorylation of Nuclear transcription factor
II- Activation of a protein kinase in the nucleus that phosphorylates specific DNA-binding proteins and thereby alters their ability to act as transcription factors.
#Question id: 4518
#Unit 3. Fundamental Processes
The sequence of transcriptional activation events at a typical Pol II promote
I- Mediator facilitates the binding of TBP (or TFIID) and TFIIB, and the other basal transcription factors and Pol II then bind.
II- Activators bind the DNA.
III-The activators recruit the histone modification/nucleosome remodeling complexes and a coactivator such as Media.
IV- Phosphorylation of the carboxyl-terminal domain (CTD) of Pol II leads to transcription initiation.
#Question id: 4519
#Unit 3. Fundamental Processes
Some steroid hormone receptors function in the nucleus as transcription activators, stimulating the transcription of certain genes when a particular steroid hormone signal is present. When the hormone is absent, the receptor proteins revert to a repressor conformation, preventing the formation of PICs. It is an example of;
#Question id: 4520
#Unit 3. Fundamental Processes
Interaction of two regulatory proteins is often mediated by domains containing