TLS Online TPP Program

#Question id: 2885


Which of the following function of DNA methylation in mammalian cell is incorrect?

#Unit 2. Cellular Organization
  1. The principal general function of DNA methylation in mammalian cells is to stabilize, or lock in, patterns of transcriptional silencing so that transcription is suppressed in highly methylated regions of chromatin.

  2. One of these is the regulation of gene expression, and it is the extent of DNA methylation in the key trans-acting regulatory elements that distinguishes actively transcribing genes from silenced genes.

  3. Highly repetitive DNA sequences, such as satellite repeats in pericentromeric heterochromatin and dispersed transposons, are extensively methylated, but there is also significant—though more sporadic—methylation in the main body (exons and introns) of genes and in intergenic regions.

  4. Patterns of gene expression that defines the identity of cells or that allow just one of the two alleles to be normally expressed can be locked in by DNA methylation.