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#XL - Q Biochemistry #Amino Acids #Part B Pointers
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Matrix-targeting sequences

Located at the N-terminus

Usually 20–50 amino acids in length

Rich in hydrophobic amino acids, positively charged basic amino acids (arginine & lysine), and hydroxylated ones (serine and threonine)

Amphipathicity of matrix-targeting sequences is critical to their function

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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GRB2 SH3 domains bind to proline-rich sequences in Sos
  

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