Binding of acetylcholine triggers the opening of an associated K+ channel  in the plasma membrane via the Gβγ subunit of a Gi protein

TLS Online TPP Program

#Id: 9662

#XL - T Zoology

The SH2 domains of PLCγ bind to specific phosphotyrosines on the activated RTKs and cytokine receptors, thus positioning PLCγ close to PIP2.

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#Id: 9663

#XL - T Zoology

Kinase activity associated with receptor activation phosphorylates tyrosines on the bound PLCγ, enhancing its hydrolase activity. 

TLS Online TPP Program

#Id: 9664

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Activated RTKs and cytokine receptors initiate another phosphoinositide pathway by recruiting PI-3 kinase to the cytosolic surface of the plasma membrane.

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#Id: 9665

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PI-3 kinase contains SH2 domain which binds to phosphotyrosines on the activated RTKs and cytokine receptors

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#Id: 9666

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PI-3 kinase adds a phosphate to the 3′ carbon in one of two separate PI substrates, leading to formation of two PI 3-phosphates: PI(3,4)P2 or PI(3,4,5)P3

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#Id: 9667

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In cells, PI-3 kinase pathway :

Triggers cell division 

Prevents apoptosis

Induces specific changes in cell metabolism