#Id: 1890
#Unit 4. Cell Communication and Cell Signaling
Two distinct selection processes are required:
• Positive selection, which selects for those thymocytes bearing receptors capable of binding self-MHC molecules, resulting in MHC restriction
• Negative selection, which selects against thymocytes bearing high-affinity receptors for self-MHC/peptide complexes, resulting in self-tolerance.