Nurturing Life Sciences
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#Unit 2. Cellular Organization
S/MARs is a DNA sequence which binds to base structure called scaffold.
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The metaphase scaffold consists of a dense network of fibers. Threads of DNA emanate from the scaffold, apparently as loops of average length 30 to 90 kb.
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S/MARs are constitutive (continuously bound to the matrix or scaffold), or facultative and change their interactions with the matrix depending on cell type or other conditions.
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SATB1, is a protein that appears to regulate the association of MARs with the matrix in order to regulate transcription of genes in the vicinity of the MAR.
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