Pattern recognition receptors (PRRs)

Receptors of the innate immune system that recognize molecular patterns or motifs present on pathogens but absent in the host.

TLS Online TPP Program

#Id: 9695

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In the basal state, 

GAPs inhibit RalA and Rab10 function by enhancing their rates of GTP hydrolysis

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#Id: 9696

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Phosphorylation of both GAPs by PKB allows RalA and the Rab10 to accumulate in their active GTP-bound states, enabling them to facilitate GSVs targeting and fusion

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#Id: 9697

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In resting cells, 

GSK3 is catalytically active which phosphorylates and inhibits glycogen synthase, thus blocking glycogen synthesis from glucose

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#Id: 9698

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In presence of insulin, 

GSK3 becomes phosphorylated by PKB its catalytic activity is inhibited

TLS Online TPP Program

#Id: 9699

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Insulin stimulated activation of PKB promotes rapid activation of glycogen synthase and glycogen synthesis

TLS Online TPP Program

#Id: 9700

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Mating pathway in the yeast S. cerevisiae, is a MAP kinase cascade which linked to GPCRs.