TLS Online TPP Program

#Question id: 13130


Biologists performed an experiment with flies to examine the effects of population size on the maintenance of genetic variation  and  on  egg-to-adult survival.  From  a  large  source  population, they  randomly  assigned  eggs  to  three experimental  populations  of  size  N,  equal  to  20,  60,  and0100.  For  later  generations,  they  collected  N  eggs  from each  population  and  moved  them  into  identical  vials  that  co0ntained  f2re0sh  me4d0ium.  Th6e0y  coun8te0d  the  number  of adult flies that emerged and used tissue samples from the adults for genetic analyses. Genetic variation was measured by  scoring  alleles  at  several  polymorphic  loci  and  expressed  as  the  average  number  of  alleles  at  those  loci.  The results are summarized in Figure 1 and Figure 2 below.


Which process best explains the dynamics of genetic variation observed in this experiment? 

#Unit 10. Ecological Principles
  1. Genetic drift 
  2. Linkage disequilibrium
  3. Mutation 
  4. Segregation distortion

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TLS Online TPP Program

#Question id: 2981

#Unit 2. Cellular Organization

For the nuclear envelope to be broken down as cells go from prophase to prometaphase during mitosis, the nuclear lamina has to be disassembled. Which of the following statement is incorrect?

TLS Online TPP Program

#Question id: 2980

#Unit 2. Cellular Organization

Following statements are regarding to the protein phosphatase Cdc14 function in budding yeast.

A. In budding yeast, the protein phosphatase Cdc14 throws the switch between two mutually antagonistic states during anaphase.

B. Cdc14 is kept inactive during most of the cell cycle, but is activated during anaphase by a GTPase signaling pathway known as the mitotic exit network.

C. Mitotic exit network is unresponsive to spindle position and becomes active in anaphase.

D. Cdc14 phosphatase activated by the activation of protein kinase cascade.

E. Cdc14 dephosphorylates APC/CCdh1 and Sic1 to promote mitotic cyclin degradation

and mitotic CDK inactivation, respectively. This process leads to exit from mitosis.

Which of the following combination is incorrect?

TLS Online TPP Program

#Question id: 2979

#Unit 2. Cellular Organization

Use the data in the accompanying table to answer the question. Minutes Spent in Cell Cycle Phases-

Cell type

G1

S

G2

M

Beta

18

24

12

16

Delta

100

1

0

0

Gamma

18

48

14

20

The data in the table were obtained from a study of the length of time spent in each phase of the cell cycle by cells of three eukaryotic organisms designated beta, delta, and gamma. What is the best explanation for the data associated with delta cells?

TLS Online TPP Program

#Question id: 2978

#Unit 2. Cellular Organization

The most important regulatory control that restricts cyclins to the appropriate cell cycle stage is ubiquitin mediated, proteasome-dependent protein degradation. Which of the following statement is incorrect regarding to the degradation of protein?

TLS Online TPP Program

#Question id: 2977

#Unit 2. Cellular Organization

The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

TLS Online TPP Program

#Question id: 2976

#Unit 2. Cellular Organization

Match the following Regulators with its functions.

Column I

Column II

A.  Wee1 kinase

i. Degradation of phosphorylated Sic1 or p27KIP1

B. Cdc25A phosphatase

ii. Induces degradation of B-type cyclins

C. APC/CCdc20

iii. Activates vertebrate S phase CDKs

D. SCF

iv. Inhibits CDKs

Which of the following is correct?