MDM2 inhibits p53  by targeting it to the ubiquitin-dependent proteosomal degradation pathway.

TLS Online TPP Program

#Id: 8329

#Unit 2. Cellular Organization

Treadmilling

Because the critical concentrations for the two ends are different, at steady state the free ATP–G-actin will be intermediate between Cc+ and Cc - , so the (+)end will grow and the (-)end will lose subunits.

TLS Online TPP Program

#Id: 8330

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8331

#Unit 2. Cellular Organization

Cytochalasin D, 

a fungal alkaloid, depolymerizes actin filaments by binding to the (+) end of F-actin.

TLS Online TPP Program

#Id: 8332

#Unit 2. Cellular Organization

Latrunculin, 

a toxin secreted by sponges, binds and sequesters G-actin

TLS Online TPP Program

#Id: 8333

#Unit 2. Cellular Organization

Jasplakinolide,

a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.

TLS Online TPP Program

#Id: 8334

#Unit 2. Cellular Organization

Phalloidin 

isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.