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TLS Online TPP Program

#Id: 7732

Atoms are indivisible particles that can't be created or destroyed in a chemical reaction.

#Section 2: General Biology #Structure of atoms #Plant Biotechnology
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TLS Online TPP Program

#Id: 7732

#Section 2: General Biology

Atoms are indivisible particles that can't be created or destroyed in a chemical reaction.
TLS Online TPP Program

#Id: 7957

#Section 3: Genetics, Cellular and Molecular Biology

Immediately after the entire precursor, Glc3Man9(GlcNAc)2 is transferred to a nascent polypeptide, three different enzymes, called  glycosidases, remove all three glucose residues and one particular mannose residue.
TLS Online TPP Program

#Id: 7956

#Section 3: Genetics, Cellular and Molecular Biology

A branched oligosaccharide containing 

3 glucose (Glc)

9 mannose (Man)

2 N-acetylglucosamine (GlcNAc)

Glc3Man9(GlcNAc)2
TLS Online TPP Program

#Id: 7955

#Section 3: Genetics, Cellular and Molecular Biology

Only asparagine residues in the tripeptide sequences Asn-X-Ser and Asn-X-Thr (where X is any amino acid except proline) are substrates for oligosaccharyl transferase.
TLS Online TPP Program

#Id: 7954

#Section 3: Genetics, Cellular and Molecular Biology

The precursor oligosaccharide is transferred from a
dolichol lipid anchor to the asparagine as an intact unit in a reaction catalyzed by a transmembrane oligosaccharyl transferase enzyme complex.
TLS Online TPP Program

#Id: 7953

#Section 3: Genetics, Cellular and Molecular Biology

Tunicamycin

blocks the first enzyme in this pathway, inhibits the synthesis of all N-linked oligosaccharides in cells.
TLS Online TPP Program

#Id: 7952

#Section 3: Genetics, Cellular and Molecular Biology

Two N- acetylglucosamine (GlcNAc) and five mannose residues are added one at a time to a dolichol phosphate on the cytosolic face of the ER membrane