When the fitness interests of two individuals are different, they are in conflict.

The evolution of cooperation and conflict depends on when these kinds of behaviors are favored by natural selection.

TLS Online TPP Program

#Id: 9481

#XL - T Zoology

TLS Online TPP Program

#Id: 9608

#XL - T Zoology

For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)

TLS Online TPP Program

#Id: 9609

#XL - T Zoology

Phosphorylation leads to a conformational change in the activation loop that unblocks kinase active site by reducing the Kd for ATP or the substrate to be phosphorylated.

TLS Online TPP Program

#Id: 9610

#XL - T Zoology

Insulin receptor, form disulfide-linked dimers in the absence of hormone.

TLS Online TPP Program

#Id: 9611

#XL - T Zoology

Binding of ligand to predimerized but inactive RTK alters the conformation of the dimer in such a way that the receptor’s kinase becomes activated.

TLS Online TPP Program

#Id: 9612

#XL - T Zoology