Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:

PINK1 (a kinase)

Parkin (E3 ubiquitin ligase)

TLS Online TPP Program

#Id: 7907

#XL - Q Biochemistry

Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:

PINK1 (a kinase)

Parkin (E3 ubiquitin ligase)

TLS Online TPP Program

#Id: 8199

#XL - Q Biochemistry

Lysosomes contain about 40 types of hydrolytic enzymes, All are acid hydrolases, work best at acidic pH including: proteases, nucleases, glycosidases, lipases, phospholipases, phosphatases, and sulfatases.

TLS Online TPP Program

#Id: 8198

#XL - Q Biochemistry

Lysosomes are membrane-enclosed organelles filled with soluble hydrolytic enzymes that digest macromolecules.

TLS Online TPP Program

#Id: 8197

#XL - Q Biochemistry

Zellweger syndrome

Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.

TLS Online TPP Program

#Id: 8196

#XL - Q Biochemistry

The AAA ATPases Pex1 and Pex6 complex use the energy from ATP hydrolysis and causing the detachment of Pex 5 receptors into cytosol.

TLS Online TPP Program

#Id: 8195

#XL - Q Biochemistry

A Pex 2, Pex 10, and Pex 12 complex embedded in the peroxisomal membrane transfers Ubiquitin to two embedded Pex 5 receptors.

TLS Online TPP Program

#Id: 8194

#XL - Q Biochemistry

After assembly of the matrix protein-Pex5-Pex14 complex, the matrix protein dissociates from Pex5 and is released into the peroxisomal matrix.