When pairs of human 23 and mouse 20 homologs are compared, the genes located on either side also tend to be homologs. This relationship is called synteny

TLS Online TPP Program

#Id: 7426

#Unit 5. Developmental Biology

During growth, unicellular D. discoideum monitor their cell density relative to that of their bacterial food source by secreting a glycoprotein called prestarvation factor at a constant rate.

TLS Online TPP Program

#Id: 7427

#Unit 5. Developmental Biology

When the ratio of PSF relative to that of bacteria exceeds a certain threshold, cells stop proliferating and initiate the expression of genes that are required for their aggregation.

TLS Online TPP Program

#Id: 7428

#Unit 5. Developmental Biology

Early on during aggregation, gene expression requires the activity of cAMP-dependent protein kinase.

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#Id: 7429

#Unit 5. Developmental Biology

High PSF to food ratio is upregulate the translation of the PKA catalytic subunit PKA-C.

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#Id: 7430

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)

TLS Online TPP Program

#Id: 7431

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signalling by inducing genes involved in cAMP synthesis and detection