He proposed that the embryonic development of an individual organism (its ontogeny) followed the same path as the evolutionary history of its species (its phylogeny).

TLS Online TPP Program

#Id: 6679

#Unit 3. Fundamental Processes

SR proteins are involved in exon definition in which they interact with U1 and U2AF forming commitment E complex.

TLS Online TPP Program

#Id: 6680

#Unit 3. Fundamental Processes

U11 base pairs with the 5’ splice sites; U12 base pairs with the branch point sequence near the 3’ splice site; and U4atac and U6atac provide analogous functions during the spliceosome assembly and activation of the spliceosome. 

U5 is same component in all splicing complexes

TLS Online TPP Program

#Id: 6681

#Unit 3. Fundamental Processes

Each snRNP contains a single snRNA (100-300 nt) and several (20) proteins. The U4 and U6 snRNPs are usually found together as a di-snRNP (U4/U6) particle.

TLS Online TPP Program

#Id: 6682

#Unit 3. Fundamental Processes

U1 snRNA consist of four hairpins, one intron pairing strands and one sm binding domains.

TLS Online TPP Program

#Id: 6683

#Unit 3. Fundamental Processes

More than 90% of the genes expressed in mammals are alternatively spliced

TLS Online TPP Program

#Id: 6684

#Unit 3. Fundamental Processes

Five ways to splice an RNA